Characterisation of Dermanyssus gallinae glutathione S-transferases and their potential as acaricide detoxification proteins.

ABSTRACT:

Background

Glutathione S-transferases (GSTs) facilitate detoxification of drugs by catalysing the conjugation of the reduced glutathione (GSH) to electrophilic xenobiotic substrates and therefore have a function in multi-drug resistance. As a result, knowledge of GSTs can inform both drug resistance in, and novel interventions for, the control of endo- and ectoparasite species. Acaricide resistance and the need for novel control methods are both pressing needs for Dermanyssus gallinae, a highly economically important haematophagous ectoparasite of poultry.

Methods

A transcriptomic database representing D. gallinae was examined and 11 contig sequences were identified with GST BlastX identities. The transcripts represented by 3 contigs, designated Deg-GST-1, -2 and -3, were fu

SUBMITTER: Bartley K 

PROVIDER: S-EPMC4491418 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature