Paving the Way to Understand Autoantibody-Mediated Epilepsy on the Molecular Level.

ABSTRACT: Correct function of neuronal networks is enabled by a delicate interplay among neurons communicating with each other. One of the keys is the communication at chemical synapses where neurotransmitters like glutamate, GABA, and glycine enable signal transfer over the synaptic cleft. Thereby, the neurotransmitters are released from the presynapse and bind as ligands to specific receptors at the postsynaptic side to allow for modulation of the postsynaptic membrane potentials. The postsynaptic electrical signal, which is highly modulated by voltage-gated ion channels, spreads over the dendritic tree and is thus integrated to allow for generation of action potentials at the axon hillock. This concert of receptors and voltage-gated ion channels depends on correct function of all its components.

SUBMITTER: Seebohm G 

PROVIDER: S-EPMC4491625 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature