Southern East Asian origin and coexpansion of Mycobacterium tuberculosis Beijing family with Han Chinese.

ABSTRACT: The Beijing family is the most successful genotype of Mycobacterium tuberculosis and responsible for more than a quarter of the global tuberculosis epidemic. As the predominant genotype in East Asia, the Beijing family has been emerging in various areas of the world and is often associated with disease outbreaks and antibiotic resistance. Revealing the origin and historical dissemination of this strain family is important for understanding its current global success. Here we characterized the global diversity of this family based on whole-genome sequences of 358 Beijing strains. We show that the Beijing strains endemic in East Asia are genetically diverse, whereas the globally emerging strains mostly belong to a more homogenous subtype known as "modern" Beijing. Phylogeographic and coalesc

SUBMITTER: Luo T 

PROVIDER: S-EPMC4491734 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature