In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging.

ABSTRACT: Cerenkov luminescence imaging utilizes visible photons emitted from radiopharmaceuticals to achieve in vivo optical molecular-derived signals. Since Cerenkov radiation is weak, non-optimum for tissue penetration and continuous regardless of biological interactions, it is challenging to detect this signal with a diagnostic dose. Therefore, it is challenging to achieve useful activated optical imaging for the acquisition of direct molecular information. Here we introduce a novel imaging strategy, which converts γ and Cerenkov radiation from radioisotopes into fluorescence through europium oxide nanoparticles. After a series of imaging studies, we demonstrate that this approach provides strong optical signals with high signal-to-background ratios, an ideal tissue penetration spectrum and acti

SUBMITTER: Hu Z 

PROVIDER: S-EPMC4491820 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature