Specific gut microbiota features and metabolic markers in postmenopausal women with obesity.

ABSTRACT:

Background

Gut microbial gene richness and specific bacterial species are associated with metabolic risk markers in humans, but the impact of host physiology and dietary habits on the link between the gut microbiota and metabolic markers remain unclear. The objective of this study was to identify gut metagenomic markers associated with estimates of insulin resistance, lipid metabolism and inflammation in obesity, and to explore whether the associations between metagenomic and metabolic markers persisted after adjustment for body fat, age and habitual dietary intake.

Methods

Faecal DNA from 53 women with obesity was analysed through quantitative metagenomic sequencing and analysis, and a systematic search was performed for bacterial genes associated with estimates of insulin

SUBMITTER: Brahe LK 

PROVIDER: S-EPMC4491860 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature