Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo.

ABSTRACT:

Background

Atherosclerosis is a heterogeneously distributed disease of arteries in which the endothelium plays an important central role. Spatial transcriptome profiling of endothelium in pre-lesional arteries has demonstrated differential phenotypes primed for athero-susceptibility at hemodynamic sites associated with disturbed blood flow. DNA methylation is a powerful epigenetic regulator of endothelial transcription recently associated with flow characteristics. We investigated differential DNA methylation in flow region-specific aortic endothelial cells in vivo in adult domestic male and female swine.

Results

Genome-wide DNA methylation was profiled in endothelial cells (EC) isolated from two robust locations of differing patho-susceptibility:--an athero-susceptible site

SUBMITTER: Jiang YZ 

PROVIDER: S-EPMC4492093 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature