Newborn screening for severe combined immunodeficiency in 11 screening programs in the United States.

ABSTRACT:

Importance

Newborn screening for severe combined immunodeficiency (SCID) using assays to detect T-cell receptor excision circles (TRECs) began in Wisconsin in 2008, and SCID was added to the national recommended uniform panel for newborn screened disorders in 2010. Currently 23 states, the District of Columbia, and the Navajo Nation conduct population-wide newborn screening for SCID. The incidence of SCID is estimated at 1 in 100,000 births.

Objectives

To present data from a spectrum of SCID newborn screening programs, establish population-based incidence for SCID and other conditions with T-cell lymphopenia, and document early institution of effective treatments.

Design

Epidemiological and retrospective observational study.

Setting

Representatives in states co

SUBMITTER: Kwan A 

PROVIDER: S-EPMC4492158 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature