Microwave & Magnetic (M²) Proteomics of a Mouse Model of Mild Traumatic Brain Injury.

ABSTRACT: Short-term increases in oxidative stress and decreases in motor function, including debilitating effects on balance and motor control, can occur following primary mild traumatic brain injuries (mTBI). However, the long-term effects on motor unit impairment and integrity as well as the molecular mechanisms underlying secondary injuries are poorly understood. We hypothesized that changes in central nervous system-specific protein (CSP) expression might correlate to these long-term effects. To test our hypothesis, we longitudinally assessed a closed-skull mTBI mouse model, vs. sham control, at 1, 7, 30, and 120 days post-injury. Motor impairment was determined by rotarod and grip strength performance measures, while motor unit integrity was determined using electromyography. Relative protein

SUBMITTER: Evans TM 

PROVIDER: S-EPMC4492171 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature