The Hand-Foot Skin Reaction and Quality of Life Questionnaire: An Assessment Tool for Oncology.

ABSTRACT:

Background

Skin toxicity (hand-foot syndrome/hand-foot skin reaction, HFS/R) related to antineoplastic therapy is a significant issue in oncology practice, with potentially large impacts on health-related quality of life (HRQL).

Materials and methods

A patient-reported questionnaire, the hand-foot skin reaction and quality of life (HF-QoL) questionnaire was developed to measure the HFS/R symptoms associated with cancer therapeutic agents and their effect on daily activities. The validity and reliability of the HF-QoL questionnaire was tested in a randomized trial of capecitabine with sorafenib/placebo in 223 patients with locally advanced/metastatic breast cancer. Other measures completed included patient ratings of condition severity, the Functional Assessment of Cancer The

SUBMITTER: Anderson RT 

PROVIDER: S-EPMC4492225 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature