Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes.

ABSTRACT: The degree of progressive chronic histological damage is associated with long-term renal allograft survival. In order to identify promising molecular targets for timely intervention, we examined renal allograft protocol and indication biopsies from 120 low-risk pediatric and adolescent recipients by whole-genome microarray expression profiling. In data-driven analysis, we found a highly regulated pattern of adaptive and innate immune gene expression that correlated with established or ongoing histological chronic injury, and also with development of future chronic histological damage, even in histologically pristine kidneys. Hence, histologically unrecognized immunological injury at a molecular level sets the stage for the development of chronic tissue injury, while the same molecular resp

SUBMITTER: Naesens M 

PROVIDER: S-EPMC4492284 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature