Ancestral Relationships Using Metafounders: Finite Ancestral Populations and Across Population Relationships.

ABSTRACT: Recent use of genomic (marker-based) relationships shows that relationships exist within and across base population (breeds or lines). However, current treatment of pedigree relationships is unable to consider relationships within or across base populations, although such relationships must exist due to finite size of the ancestral population and connections between populations. This complicates the conciliation of both approaches and, in particular, combining pedigree with genomic relationships. We present a coherent theoretical framework to consider base population in pedigree relationships. We suggest a conceptual framework that considers each ancestral population as a finite-sized pool of gametes. This generates across-individual relationships and contrasts with the classical view whic

SUBMITTER: Legarra A 

PROVIDER: S-EPMC4492372 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature