Reconstructing Past Admixture Processes from Local Genomic Ancestry Using Wavelet Transformation.

ABSTRACT: Admixture between long-separated populations is a defining feature of the genomes of many species. The mosaic block structure of admixed genomes can provide information about past contact events, including the time and extent of admixture. Here, we describe an improved wavelet-based technique that better characterizes ancestry block structure from observed genomic patterns. principal components analysis is first applied to genomic data to identify the primary population structure, followed by wavelet decomposition to develop a new characterization of local ancestry information along the chromosomes. For testing purposes, this method is applied to human genome-wide genotype data from Indonesia, as well as virtual genetic data generated using genome-scale sequential coalescent simulations un

SUBMITTER: Sanderson J 

PROVIDER: S-EPMC4492373 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature