Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome.

ABSTRACT: In mammals, several classes of monoallelic genes have been identified, including those subject to X-chromosome inactivation (XCI), genomic imprinting, and random monoallelic expression (RMAE). However, the extent to which these epigenetic phenomena are influenced by underlying genetic variation is unknown. Here we perform a systematic classification of allelic imbalance in mouse hybrids derived from reciprocal crosses of divergent strains. We observe that deviation from balanced biallelic expression is common, occurring in ∼20% of the mouse transcriptome in a given tissue. Allelic imbalance attributed to genotypic variation is by far the most prevalent class and typically is tissue-specific. However, some genotype-based imbalance is maintained across tissues and is associated with greater

SUBMITTER: Pinter SF 

PROVIDER: S-EPMC4492378 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature