A Composite-Likelihood Method for Detecting Incomplete Selective Sweep from Population Genomic Data.

ABSTRACT: Adaptive evolution occurs as beneficial mutations arise and then increase in frequency by positive natural selection. How, when, and where in the genome such evolutionary events occur is a fundamental question in evolutionary biology. It is possible to detect ongoing positive selection or an incomplete selective sweep in species with sexual reproduction because, when a beneficial mutation is on the way to fixation, homologous chromosomes in the population are divided into two groups: one carrying the beneficial allele with very low polymorphism at nearby linked loci and the other carrying the ancestral allele with a normal pattern of sequence variation. Previous studies developed long-range haplotype tests to capture this difference between two groups as the signal of an incomplete selecti

SUBMITTER: Vy HM 

PROVIDER: S-EPMC4492385 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature