Spatiotemporal dynamics of the postnatal developing primate brain transcriptome.

ABSTRACT: Developmental changes in the temporal and spatial regulation of gene expression drive the emergence of normal mature brain function, while disruptions in these processes underlie many neurodevelopmental abnormalities. To solidify our foundational knowledge of such changes in a primate brain with an extended period of postnatal maturation like in human, we investigated the whole-genome transcriptional profiles of rhesus monkey brains from birth to adulthood. We found that gene expression dynamics are largest from birth through infancy, after which gene expression profiles transition to a relatively stable state by young adulthood. Biological pathway enrichment analysis revealed that genes more highly expressed at birth are associated with cell adhesion and neuron differentiation, while gene

SUBMITTER: Bakken TE 

PROVIDER: S-EPMC4492396 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature