The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.

ABSTRACT: A major milestone of child development is the acquisition and use of speech and language. Communication disorders, including speech sound disorder (SSD), can impair a child's academic, social and behavioral development. Speech sound disorder is a complex, polygenic trait with a substantial genetic component. However, specific genes that contribute to SSD remain largely unknown. To identify associated genes, we assessed the association of the DYX2 dyslexia risk locus and markers in neurochemical signaling genes (e.g., nicotinic and dopaminergic) with SSD and related endophenotypes. We first performed separate primary associations in two independent samples - Cleveland SSD (210 affected and 257 unaffected individuals in 127 families) and Denver SSD (113 affected individuals and 106 unaffecte

SUBMITTER: Eicher JD 

PROVIDER: S-EPMC4492462 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature