Ontology highlight
ABSTRACT:
SUBMITTER: Wolfe AL
PROVIDER: S-EPMC4492470 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Nature 20140727 7516
The translational control of oncoprotein expression is implicated in many cancers. Here we report an eIF4A RNA helicase-dependent mechanism of translational control that contributes to oncogenesis and underlies the anticancer effects of silvestrol and related compounds. For example, eIF4A promotes T-cell acute lymphoblastic leukaemia development in vivo and is required for leukaemia maintenance. Accordingly, inhibition of eIF4A with silvestrol has powerful therapeutic effects against murine and ...[more]