Targeting Histone Deacetylases in Diseases: Where Are We?

ABSTRACT:

Significance

Epigenetic inactivation of pivotal genes involved in cell growth is a hallmark of human pathologies, in particular cancer. Histone acetylation balance obtained through opposing actions of histone deacetylases (HDACs) and histone acetyltransferases is one epigenetic mechanism controlling gene expression and is, thus, associated with disease etiology and progression. Interfering pharmacologically with HDAC activity can correct abnormalities in cell proliferation, migration, vascularization, and death.

Recent advances

Histone deacetylase inhibitors (HDACi) represent a new class of cytostatic agents that interfere with the function of HDACs and are able to increase gene expression by indirectly inducing histone acetylation. Several HDACi, alone or in combination wit

SUBMITTER: Benedetti R 

PROVIDER: S-EPMC4492558 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature