Baseline Platelet Activation and Reactivity in Patients with Critical Limb Ischemia.

ABSTRACT:

Background

Patients with critical limb ischemia (CLI) have a high risk to develop cardiovascular events (CVE). We hypothesized that in CLI patients platelets would display increased baseline activation and reactivity.

Objectives

We investigated baseline platelet activation and platelet reactivity in patients with CLI.

Patients/methods

In this study baseline platelet activation and platelet reactivity in response to stimulation of all major platelet activation pathways were determined in 20 CLI patients (11 using aspirin and 9 using vitamin K-antagonists) included in the Juventas-trial (clinicaltrials.gov NCT00371371) and in 17 healthy controls. Platelet activation was quantified with flow cytometric measurement of platelet P-selectin expression and fibrinogen binding.

SUBMITTER: Wisman PP 

PROVIDER: S-EPMC4492682 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature