Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study.

ABSTRACT:

Aims/hypothesis

Few studies have explored the epidemiology of beta cell loss in youth with diabetes. This report describes the evolution and major determinants of beta cell function, assessed by fasting C-peptide (FCP), in the SEARCH for Diabetes in Youth study.

Methods

Participants were 1,277 youth with diabetes (948 positive for diabetes autoantibodies [DAs] and 329 negative for DAs), diagnosed when aged <20 years, who were followed from a median of 8 months post diagnosis, for approximately 30 months. We modelled the relationship between rate of change in log FCP and determinants of interest using repeated measures general linear models.

Results

Among DA-positive youth, there was a progressive decline in beta cell function of 4% per month, independent of demographi

SUBMITTER: Dabelea D 

PROVIDER: S-EPMC4492685 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature