Widespread epileptic networks in focal epilepsies: EEG-fMRI study.

ABSTRACT:

Purpose

To assess the extent of brain involvement during focal epileptic activity, we studied patterns of cortical and subcortical metabolic changes coinciding with interictal epileptic discharges (IEDs) using group analysis of simultaneous electroencephalography and functional magnetic resonance imaging (EEG-fMRI) scans in patients with focal epilepsy.

Methods

We selected patients with temporal lobe epilepsy (TLE, n = 32), frontal lobe epilepsy (FLE, n = 14), and posterior quadrant epilepsy (PQE, n = 20) from our 3 Tesla EEG-fMRI database. We applied group analysis upon the blood oxygen-level dependent (BOLD) response associated with focal IEDs.

Key findings

Patients with TLE and FLE showed activations and deactivations, whereas in PQE only deactivations occurred. In

SUBMITTER: Fahoum F 

PROVIDER: S-EPMC4492710 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature