Metabolomic analysis to define and compare the effects of PAHs and oxygenated PAHs in developing zebrafish.

ABSTRACT: Polycyclic aromatic hydrocarbons (PAHs) and their oxygenated derivatives are ubiquitously present in diesel exhaust, atmospheric particulate matter and soils sampled in urban areas. Therefore, inhalation or non-dietary ingestion of both PAHs and oxy-PAHs are major routes of exposure for people; especially young children living in these localities. While there has been extensive research on the parent PAHs, limited studies exist on the biological effects of oxy-PAHs which have been shown to be more soluble and more mobile in the environment. Additionally, investigations comparing the metabolic responses resulting from parent PAHs and oxy-PAHs exposures have not been reported. To address these current gaps, an untargeted metabolomics approach was conducted to examine the in vivo metabolomic

SUBMITTER: Elie MR 

PROVIDER: S-EPMC4492807 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature