Intergenerational reduction in Helicobacter pylori prevalence is similar between different ethnic groups living in a Western city.

ABSTRACT:

Objective

Helicobacter pylori colonisation rates in childhood have declined in Western populations, but it is unknown whether this trend is similar in children of non-Western ethnic backgrounds, born in a Western country. We aimed to identify H. pylori status in children, and determine mother-to-child transmission and risk factors for colonisation.

Design

Antibodies against H. pylori and cytotoxin-associated gene A (CagA) were measured in children participating in a population-based prospective cohort study in Rotterdam, the Netherlands. Information on demographics and characteristics was collected using questionnaires.

Results

We analysed the serum of 4467 children (mean age 6.2 years±0.4 SD) and compared the results with the H. pylori status of their mothers (availa

SUBMITTER: den Hollander WJ 

PROVIDER: S-EPMC4492887 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature