White matter abnormalities of microstructure and physiological noise in schizophrenia.

ABSTRACT: White matter abnormalities in schizophrenia have been revealed by many imaging techniques and analysis methods. One of the findings by diffusion tensor imaging is a decrease in fractional anisotropy (FA), which is an indicator of white matter integrity. On the other hand, elevation of metabolic rate in white matter was observed from positron emission tomography (PET) studies. In this report, we aim to compare the two structural and functional effects on the same subjects. Our comparison is based on the hypothesis that signal fluctuation in white matter is associated with white matter functional activity. We examined the variance of the signal in resting state fMRI and found significant differences between individuals with schizophrenia and non-psychiatric controls specifically in white mat

SUBMITTER: Cheng H 

PROVIDER: S-EPMC4492900 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature