Differential Activation of Human Monocytes and Lymphocytes by Distinct Strains of Trypanosoma cruzi.

ABSTRACT:

Background

Trypanosoma cruzi strains are currently classified into six discrete typing units (DTUs) named TcI to VI. It is known that these DTUs have different geographical distribution, as well as biological features. TcI and TcII are major DTUs found in patients from northern and southern Latin America, respectively. Our hypothesis is that upon infection of human peripheral blood cells, Y strain (Tc II) and Col cl1.7 (Tc I), cause distinct immunological changes, which might influence the clinical course of Chagas disease.

Methodology/principal findings

We evaluated the infectivity of CFSE-stained trypomastigotes of Col cl1.7 and Y strain in human monocytes for 15 and 72 hours, and determined the immunological profile of lymphocytes and monocytes exposed to the different is

SUBMITTER: Magalhaes LM 

PROVIDER: S-EPMC4492932 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature