Cortisol and α-Amylase Secretion Patterns between and within Depressed and Non-Depressed Individuals.

ABSTRACT:

Objectives

Associations between biological stress markers and depression are inconsistent across studies. We assessed whether inter- and intra-individual variability explain these inconsistencies.

Methods

Pair-matched depressed and non-depressed participants (N = 30) collected saliva thrice a day for 30 days, resulting in 90 measurements per individual. The relationships between measures of stress-system function and depression were examined at the group level by means of mixed model analyses, and at the individual level by means of pair-matched comparisons. The analyses were repeated after adjusting for time-varying lifestyle factors by means of time-series regression analyses.

Results

Cortisol and α-amylase levels were higher, the α-amylase/cortisol ratio larger, an

SUBMITTER: Booij SH 

PROVIDER: S-EPMC4492984 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature