Central Autonomic Dysfunction Delays Recovery of Fingolimod Induced Heart Rate Slowing.

ABSTRACT:

Background

In multiple sclerosis (MS) patients, Fingolimod may induce prolonged heart-rate slowing which might be caused by MS-related central autonomic lesions.

Objectives

To evaluate whether MS-patients with prolonged heart-rate slowing (> six hours) upon Fingolimod show cardiovascular-autonomic dysfunction before Fingolimod-initiation.

Methods

Before Fingolimod-initiation, we recorded electrocardiographic RR-intervals (RRIs) and blood-pressure (BP) at rest, upon standing-up, during metronomic deep-breathing, Valsalva-maneuver, and "sustained-handgrip-exercise" in 21 patients with relapsing-remitting MS, and 20 healthy persons. We calculated sympathetic and parasympathetic cardiovascular parameters, including low- (LF) and high-frequency (HF) powers of RRI- and BP-o

SUBMITTER: Hilz MJ 

PROVIDER: S-EPMC4493029 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature