Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster.

ABSTRACT: Lipid droplets (LDs) are common organelles of the majority of eukaryotic cell types. Their biological significance has been extensively studied in mammalian liver cells and white adipose tissue. Although the central nervous system contains the highest relative amount and the largest number of different lipid species, neither the spatial nor the temporal distribution of LDs has been described. In this study, we used the brain of the fruitfly, Drosophila melanogaster, to investigate the neuroanatomy of LDs. We demonstrated that LDs are exclusively localised in glial cells but not in neurons in the larval nervous system. We showed that the brain's LD pool, rather than being constant, changes dynamically during development and reaches its highest value at the beginning of metamorphosis. LDs ar

SUBMITTER: Kis V 

PROVIDER: S-EPMC4493057 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature