Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans.

ABSTRACT:

Introduction

Diverse and multi-factorial processes contribute to the progression of cardiovascular disease. These processes affect cells involved in the development of this disease in varying ways, ultimately leading to atherothrombosis. The goal of our study was to compare the differential effects of specific stimuli--two bacterial infections and a Western diet--on platelet responses in ApoE-/- mice, specifically examining inflammatory function and gene expression. Results from murine studies were verified using platelets from participants of the Framingham Heart Study (FHS; n = 1819 participants).

Methods

Blood and spleen samples were collected at weeks 1 and 9 from ApoE-/- mice infected with Porphyromonas gingivalis or Chlamydia pneumoniae and from mice fed a Western diet

SUBMITTER: Beaulieu LM 

PROVIDER: S-EPMC4493099 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature