Controlled Delivery of Human Cells by Temperature Responsive Microcapsules.

ABSTRACT: Cell therapy is one of the most promising areas within regenerative medicine. However, its full potential is limited by the rapid loss of introduced therapeutic cells before their full effects can be exploited, due in part to anoikis, and in part to the adverse environments often found within the pathologic tissues that the cells have been grafted into. Encapsulation of individual cells has been proposed as a means of increasing cell viability. In this study, we developed a facile, high throughput method for creating temperature responsive microcapsules comprising agarose, gelatin and fibrinogen for delivery and subsequent controlled release of cells. We verified the hypothesis that composite capsules combining agarose and gelatin, which possess different phase transition temperatures from

SUBMITTER: Mak WC 

PROVIDER: S-EPMC4493523 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature