Protein alterations in women with chronic widespread pain--An explorative proteomic study of the trapezius muscle.

ABSTRACT: Chronic widespread pain (CWP) has a high prevalence in the population and is associated with prominent negative individual and societal consequences. There is no clear consensus concerning the etiology behind CWP although alterations in the central processing of nociception maintained by peripheral nociceptive input has been suggested. Here, we use proteomics to study protein changes in trapezius muscle from 18 female patients diagnosed with CWP compared to 19 healthy female subjects. The 2-dimensional gel electrophoresis (2-DE) in combination with multivariate statistical analyses revealed 17 proteins to be differently expressed between the two groups. Proteins were identified by mass spectrometry. Many of the proteins are important enzymes in metabolic pathways like the glycolysis and gl

SUBMITTER: Olausson P 

PROVIDER: S-EPMC4493691 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature