Transcriptome analysis of basal and luminal tumor-initiating cells in ErbB2-driven breast cancer.

ABSTRACT: Breast cancer is the leading cause of cancer-related mortality for females worldwide.¹ Improving early screening strategies and understanding the events that lead to tumor initiation have led to demonstrable improvements in clinical outcome. Our previous work revealed a variance in the tumorigenic capacity between different mammary epithelial cell populations in an MMTV-ErbB2 mouse model. In order to greater understand how different mammary epithelial cells influence the tumorigenic capacity in ErbB2-induced breast cancer, we transplanted different cell populations from pre-neoplastic MMTV-ErbB2 female mice into recipient mice for tumorigenic study. We found that different mammary epithelial cells bear different tumorigenic potential even when induced by the same E

SUBMITTER: Borcherding N 

PROVIDER: S-EPMC4493742 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature