Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism.

ABSTRACT:

Introduction

Recurrent venous thromboembolism (VTE) occurs infrequently following a provoked event but occurs in up to 30% of individuals following an initial unprovoked event. There is limited understanding of the biological mechanisms that predispose patients to recurrent VTE.

Objectives

To identify whole blood gene expression profiles that distinguished patients with clinically distinct patterns of VTE.

Patients/methods

We studied 107 patients with VTE separated into 3 groups: (1) 'low-risk' patients had one or more provoked VTE; (2) 'moderate-risk' patients had a single unprovoked VTE; (3) 'high-risk' patients had ≥2 unprovoked VTE. Each patient group was also compared to twenty-five individuals with no personal history of VTE. Total RNA from whole blood was isola

SUBMITTER: Lewis DA 

PROVIDER: S-EPMC4493863 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature