Synthesis of 2-Acylphenol and Flavene Derivatives from the Ruthenium-Catalyzed Oxidative C-H Acylation of Phenols with Aldehydes.

ABSTRACT: The cationic ruthenium hydride complex [(C₆H₆)(PCy₃)(CO)RuH]⁺BF₄^- has been found to be an effective catalyst for the oxidative C-H coupling reaction of phenols with aldehydes to give 2-acylphenol compounds. The coupling of phenols with α,β-unsaturated aldehydes selectively gives the flavene derivatives. The catalytic method mediates direct oxidative C-H coupling of phenol and aldehyde substrates without using any metal oxidants or forming wasteful byproducts.

SUBMITTER: Lee H 

PROVIDER: S-EPMC4493914 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature