Relationship Between Cortical Thickness and Functional Activation in the Early Blind.

ABSTRACT: Early blindness results in both structural and functional changes of the brain. However, these changes have rarely been studied in relation to each other. We measured alterations in cortical thickness (CT) caused by early visual deprivation and their relationship with cortical activity. Structural and functional magnetic resonance imaging was performed in 12 early blind (EB) humans and 12 sighted controls (SC). Experimental conditions included one-back tasks for auditory localization and pitch identification, and a simple sound-detection task. Structural and functional data were analyzed in a whole-brain approach and within anatomically defined regions of interest in sensory areas of the spared (auditory) and deprived (visual) modalities. Functional activation during sound-localization or

SUBMITTER: Anurova I 

PROVIDER: S-EPMC4494021 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature