Dual Organellar Targeting of Aminoacyl-tRNA Synthetases in Diatoms and Cryptophytes.

ABSTRACT: The internal compartmentation of eukaryotic cells not only allows separation of biochemical processes but it also creates the requirement for systems that can selectively transport proteins across the membrane boundaries. Although most proteins function in a single subcellular compartment, many are able to enter two or more compartments, a phenomenon known as dual or multiple targeting. The aminoacyl-tRNA synthetases (aaRSs), which catalyze the ligation of tRNAs to their cognate amino acids, are particularly prone to functioning in multiple subcellular compartments. They are essential for translation, so they are required in every compartment where translation takes place. In diatoms, there are three such compartments, the plastid, the mitochondrion, and the cytosol. In cryptophytes, trans

SUBMITTER: Gile GH 

PROVIDER: S-EPMC4494062 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature