The evolutionary fate of alternatively spliced homologous exons after gene duplication.

ABSTRACT: Alternative splicing and gene duplication are the two main processes responsible for expanding protein functional diversity. Although gene duplication can generate new genes and alternative splicing can introduce variation through alternative gene products, the interplay between the two processes is complex and poorly understood. Here, we have carried out a study of the evolution of alternatively spliced exons after gene duplication to better understand the interaction between the two processes. We created a manually curated set of 97 human genes with mutually exclusively spliced homologous exons and analyzed the evolution of these exons across five distantly related vertebrates (lamprey, spotted gar, zebrafish, fugu, and coelacanth). Most of these exons had an ancient origin (more than 40

SUBMITTER: Abascal F 

PROVIDER: S-EPMC4494069 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature