The effect of secondary prophylaxis versus episodic treatment on the range of motion of target joints in patients with haemophilia.

ABSTRACT: This study prospectively compared the effect of secondary prophylaxis to episodic treatment on target joint (TJ) range of motion (ROM), number of joint haemorrhages and new TJ development in patients with moderate or severe haemophilia. Two-hundred and eighty-six males, 17% in prophylaxis, 83% in episodic treatment group, participating in the Centers for Disease Control and Prevention's Universal Data Collection project, fulfilled inclusion criteria: age >2 years at enrollment, free of TJs at enrollment, developed at least one TJ after enrollment, and received either prophylaxis or episodic treatment continuously for two follow-up visits after TJ development. The outcomes of interest - percentage change in TJ ROM, number of joint haemorrhages and new TJ development, were modelled using mul

SUBMITTER: Gupta S 

PROVIDER: S-EPMC4494109 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature