Investigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran.

ABSTRACT:

Background

Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disease of the Central Nervous System that is immunologically mediated in genetically susceptible individuals. IL-21, a cytokine produced by TCD4(+) cells, particularly by Th-17 cells, is believed to play an important role in the MS pathogenesis.

Objective

This study was performed to investigate the impact of genetic polymorphisms in IL-21 gene on MS susceptibility and clinical profiles.

Methods

Seventy Iranian patients with clinically definite relapsing-remitting MS and 110 age, sex and ethic matched controls were genotyped for IL-21 gene polymorphisms using PCR-RFLP method.

Results

Our results showed that the IL-21 rs2221903 SNP is not polymorphic in our population. Also, the allelic a

SUBMITTER: Gharibi T 

PROVIDER: S-EPMC4494115 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature