Novel GMO-Based Vaccines against Tuberculosis: State of the Art and Biosafety Considerations.

ABSTRACT: Novel efficient vaccines are needed to control tuberculosis (TB), a major cause of morbidity and mortality worldwide. Several TB vaccine candidates are currently in clinical and preclinical development. They fall into two categories, the one of candidates designed as a replacement of the Bacille Calmette Guérin (BCG) to be administered to infants and the one of sub-unit vaccines designed as booster vaccines. The latter are designed as vaccines that will be administered to individuals already vaccinated with BCG (or in the future with a BCG replacement vaccine). In this review we provide up to date information on novel tuberculosis (TB) vaccines in development focusing on the risk assessment of candidates composed of genetically modified organisms (GMO) which are currently evaluated in clin

SUBMITTER: Leunda A 

PROVIDER: S-EPMC4494264 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature