The reduction of volume and fiber bundle connections in the hippocampus of EGR3 transgenic schizophrenia rats.

ABSTRACT:

Background and objective

There is a growing consensus that schizophrenia is ultimately caused by abnormal communication between spatially disparate brain structures. White matter fasciculi represent the primary infrastructure for long distance communication in the brain. In this study, we aimed to investigate the white matter connection in schizophrenia susceptible brain regions of early growth response factor 3 (EGR3) expressing rats.

Methods

A rat model of schizophrenia was created by the transfection of the EGR3 gene into rat hippocampus. All animals were placed in a fixation system using a commercial rat-dedicated coil. Schizophrenia susceptible brain regions were scanned using in vivo diffusion tensor magnetic resonance imaging. The volume, quantity, average length of f

SUBMITTER: Ma E 

PROVIDER: S-EPMC4494618 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature