Evaluation of coronary adventitial vasa vasorum using 3D optical coherence tomography--animal and human studies.

ABSTRACT:

Objectives

This study sought to evaluate adventitial vasa vasorum (VV) in vivo with novel imaging technique of optical coherence tomography (OCT).

Methods

To verify OCT methods for quantification of VV, we first studied 2 swine carotid arteries in a model of focal angiogenesis by autologous blood injection, and compared microchannel volume (MCV) by OCT and VV by m-CT, and counts of those. In OCT images, adventitial MC was identified as signal-voiding areas which were located within 1 mm from the lumen-intima border. After manually tracing microchannel areas and the boundaries of lumen-intima and media-adventitial in all slices, we reconstructed 3D images. Moreover, we performed with OCT imaging in 8 recipients referred for evaluation of cardiac allograft vasculopathy at 1 ye

SUBMITTER: Aoki T 

PROVIDER: S-EPMC4494669 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature