Early inflammation in the absence of overt infection in preterm neonates exposed to intensive care.

ABSTRACT:

Background

Systemic inflammation, typically attributed to sepsis, has been repeatedly linked to adverse long-term outcomes in infants born prematurely. However, it is unclear whether other factors can contribute to potentially harmful systemic inflammatory responses.

Objective

To determine the timing and extent of systemic inflammation occurring in absence of infection in preterm infants exposed to intensive care.

Methods

First, we screened for inflammation biomarkers most strongly linked to infection in a large prospective cohort of 425 newborns (gestational age 24-42 weeks). Second, we longitudinally measured levels of infection-related inflammation biomarkers up to 42 days of post-natal life in a series of 58 infants born ≤30 weeks of gestation exposed to intensive

SUBMITTER: Chang BA 

PROVIDER: S-EPMC4494824 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature