Drug Dosing and Pharmacokinetics in Children With Obesity: A Systematic Review.

ABSTRACT:

Importance

Obesity affects nearly one-sixth of US children and results in alterations to body composition and physiology that can affect drug disposition, possibly leading to therapeutic failure or toxic side effects. The depth of available literature regarding obesity's effect on drug safety, pharmacokinetics, and dosing in obese children is unknown.

Objective

To perform a systematic literature review describing the current evidence of the effect of obesity on drug disposition in children.

Evidence review

We searched the MEDLINE, Cochrane, and EMBASE databases (January 1, 1970-December 31, 2012) and included studies if they contained data on drug clearance, volume of distribution, or drug concentration in obese children (aged ≤18 years). We compared exposure and weig

SUBMITTER: Harskamp-van Ginkel MW 

PROVIDER: S-EPMC4494887 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature