RAB7 counteracts PI3K-driven macropinocytosis activated at early stages of melanoma development.

ABSTRACT: Derailed endolysosomal trafficking is emerging as a widespread feature of aggressive neoplasms. However, the oncogenic signals that alter membrane homeostasis and their specific contribution to cancer progression remain unclear. Understanding the upstream drivers and downstream regulators of aberrant vesicular trafficking is distinctly important in melanoma. This disease is notorious for its inter- and intra-tumoral heterogeneity. Nevertheless, melanomas uniformly overexpress a cluster of endolysosomal genes, being particularly addicted to the membrane traffic regulator RAB7. Still, the underlying mechanisms and temporal determinants of this dependency have yet to be defined. Here we addressed these questions by combining electron microscopy, real time imaging and mechanistic analyses of v

SUBMITTER: Alonso-Curbelo D 

PROVIDER: S-EPMC4494909 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature