Comparative Safety of Testosterone Dosage Forms.

ABSTRACT:

Importance

Increases in testosterone use and mixed reports of adverse events have raised concerns about the cardiovascular safety of testosterone. Testosterone is available in several delivery mechanisms with varying pharmacokinetics; injections cause spikes in testosterone levels, and transdermal patches and gels cause more subtle but sustained increases. The comparative cardiovascular safety of gels, injections, and patches has not been studied.

Objective

To determine the comparative cardiovascular safety of testosterone injections, patches, and gels.

Design, setting, and participants

A retrospective cohort study was conducted using administrative claims from a commercially insured (January 1, 2000, to December 31, 2012) and Medicare (January 1, 2007, to December 31

SUBMITTER: Layton JB 

PROVIDER: S-EPMC4494981 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature