Persistence of asthma requires multiple feedback circuits involving type 2 innate lymphoid cells and IL-33.

ABSTRACT:

Background

Asthma in a mouse model spontaneously resolves after cessation of allergen exposure. We developed a mouse model in which asthma features persisted for 6 months after cessation of allergen exposure.

Objective

We sought to elucidate factors contributing to the persistence of asthma.

Methods

We used a combination of immunologic, genetic, microarray, and pharmacologic approaches to dissect the mechanism of asthma persistence.

Results

Elimination of T cells though antibody-mediated depletion or lethal irradiation and transplantation of recombination-activating gene (Rag1)(-/-) bone marrow in mice with chronic asthma resulted in resolution of airway inflammation but not airway hyperreactivity or remodeling. Elimination of T cells and type 2 innate lymphoid

SUBMITTER: Christianson CA 

PROVIDER: S-EPMC4494983 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature