Sputum induction improves detection of pathogens in children with cystic fibrosis.

ABSTRACT:

Background

Sputum induction is a safe, well tolerated means of obtaining lower airway secretions from children with cystic fibrosis (CF), particularly for assessment of airway inflammation but the clinical value in diagnosing outpatient infections has not been extensively studied.

Objectives

Investigate the success rate and microbiologic yield of induced sputum (IS) compared to oropharyngeal swabs (OP) and expectorated sputum (ES) samples in children with CF, and determine if IS culture results impact treatment.

Methods

Two cohorts were included in this prospective, longitudinal comparative study. In one cohort, simultaneously collected OP, ES, and IS specimens were obtained from 17 CF children at three visits over 1 year. In the second group, sputum induction was per

SUBMITTER: Hoppe JE 

PROVIDER: S-EPMC4495008 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature