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Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-N-(4,5-dihydro-5-oxo-1H-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity.

ABSTRACT:

Abstract

A series of novel 4-chloro-N-(4,5-dihydro-5-oxo-1-R2-1H-1,2,4-triazol-3-yl)-5-methyl-2-(R1-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute (NCI) against the NCI-60 cell line panel. The most prominent compound showed remarkable activity against 13 human tumor cell lines representing lung, colon, CNS, melanoma, ovarian, renal, prostate, and breast at low micromolar GI50 level in the range of 1.9-3.0 μM.

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SUBMITTER: Slawinski J 

PROVIDER: S-EPMC4495025 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Synthesis and molecular structure of novel 2-(alkylthio)-4-chloro-<i>N</i>-(4,5-dihydro-5-oxo-1<i>H</i>-1,2,4-triazol-3-yl)-5-methylbenzenesulfonamides with potential anticancer activity.

Sławiński Jarosław J   Żołnowska Beata B   Orlewska Czesława C   Chojnacki Jarosław J  

Monatshefte fur chemie 20120925 12

<h4>Abstract</h4>A series of novel 4-chloro-<i>N</i>-(4,5-dihydro-5-oxo-1-R<sup>2</sup>-1<i>H</i>-1,2,4-triazol-3-yl)-5-methyl-2-(R<sup>1</sup>-methylthio)benzenesulfonamide derivatives have been synthesized as potential anticancer agents. The in vitro antitumor activity of some compounds was evaluated in the US National Cancer Institute (NCI) against the NCI-60 cell line panel. The most prominent compound showed remarkable activity against 13 human tumor cell lines representing lung, colon, CNS  ...[more]

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