Neural stem cell progeny regulate stem cell death in a Notch and Hox dependent manner.

ABSTRACT: Cell death is a prevalent, well-controlled and fundamental aspect of development, particularly in the nervous system. In Drosophila, specific neural stem cells are eliminated by apoptosis during embryogenesis. In the absence of apoptosis, these stem cells continue to divide, resulting in a dramatically hyperplastic central nervous system and adult lethality. Although core cell death pathways have been well described, the spatial, temporal and cell identity cues that activate the cell death machinery in specific cells are largely unknown. We identified a cis-regulatory region that controls the transcription of the cell death activators reaper, grim and sickle exclusively in neural stem cells. Using a reporter generated from this regulatory region, we found that Notch activity is required fo

SUBMITTER: Arya R 

PROVIDER: S-EPMC4495361 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature